In this study, we sought to investigate association of the reported top GWAS signals (i.e., ARID5B, IKZF1, GATA3, PIP4K2A, CEBPE, and ERG) with ALL susceptibility in all-age Chinese patients, and also estimate the impact of BCR-ABL fusion and age at diagnosis. This evidence concerns the gene PIP4K2A and acute lymphoblastic leukemia.