Our study showed that the prognostic signature-based risk score, which was positively associated with the expression levels of KIAA1429, RBM15, and HNRNPC, was an independent prognostic factor for each lung adenocarcinoma patient, indicating that KIAA1429, RBM15, and HNRNPC all might function as oncogenes in lung adenocarcinoma. The gene discussed is VIRMA; the disease is lung adenocarcinoma.