Interestingly, Deng et al. have found that overexpression of METTL3 inhibits the proliferation, migration and invasion of colorectal cancer cells, while knockdown of METTL3 significantly reverses the effect on proliferation, migration and invasion, indicating that METTL3 plays a tumor-suppressive role in colorectal cancer (Deng et al., 2019). This evidence concerns the gene METTL3 and colorectal cancer.