CCN2 and fibrosis: Serum: IL-1β↓, TNF-α↓, Blood: glucose ↓ Creatinine ↓, Blood urine nitrogen ↓, Kidney: Bax ↓, Bcl-2 ↑, Apoptosis ↓, Mesangial expansion ↓, Mesangial expansion ↓, Interstitial fibrosis ↓, Collagen Ia2 ↓, Collagen III, CTGF, α-SMA) ↓, Infiltrating macrophages ↓, MCP-1 ↓ Albuminuria ↓, Podocyte loss ↓