TNF and diabetic kidney disease: Additionally, the OE of miRNA-874 in kidney by injecting adenovirus carrying an miR-874 mimic was shown to significantly decrease the infiltration of inflammatory cells and the expression levels of inflammatory cytokines such as IL-6, IL-1β, and TNF-α with inhibition of the expression of TLR4 in kidney, resulting in decreased albuminuria and increased renal function in a rat diabetic nephropathy model in vivo (Yao et al., 2018).