Serum: Diabetes-induced hyperfiltration ↓, Creatinine clearance ↑ Kidney: Kidney weight ↓, Urinary protein levels ↓, Glomerular hypertrophy ↓, Desmin ↓, Apotosis ↓, Nephrin ↑, WT-1 ↑, TGF-β1 ↓, Fibronectin ↓, IL-1β↓. The gene discussed is DES; the disease is diabetes mellitus.