The variant rs6318 also regulates the expression level of IL13RA2 in the putamen; it is only polymorphic in the cohort under study but was previously associated with a number of phenotypes relevant to the pathogenesis of depression and to effects of psychotropic drugs (Drago and Serretti, 2009; Mickey et al., 2012; Brummett et al., 2014; Karanovic et al., 2015; Avery and Vrshek-Schallhorn, 2016; Chagraoui et al., 2016; Vyalova et al., 2017). The gene discussed is IL13RA2; the disease is major depressive disorder.