Absence of response on the 28th day assessed by the HDRS-17 or CGI-I scale among patients with depression might be predicted by alleles of the variant NC_000008.11:g.32614509_32614510del in NRG1 and of the two variants in PIP4K2A: rs61731109 and rs10508649. The gene discussed is NRG1; the disease is major depressive disorder.