On the other hand, knowing that serotonin leads to inhibition of KCNQ/M-channels (Colino and Halliwell, 1987; Stephens et al., 2018) and inflammation leads to production of reactive oxygen species resulting in increased neuronal excitability (Berridge, 2014), NRG1, PIP4K2A, HTR2C, and IL13RA2 may have further interconnected roles in the pathophysiology of depressive and manic episodes and the response to antidepressant medication. Here, IL13RA2 is linked to manic or hypomanic episode.