PPP2CA codes for the protein phosphatase 2 catalytic subunit α of protein phosphatase 2A (PP2A), an important component of AKT/GSK3 signaling implicated in a number of psychiatric disorders, including depression and bipolar disorder (Beaulieu, 2012), as well as response to psychotropic drugs, including antidepressants and lithium (Beaulieu et al., 2009). The gene discussed is AKT1; the disease is major depressive disorder.