PPP2CA and major depressive disorder: PPP2CA codes for the protein phosphatase 2 catalytic subunit α of protein phosphatase 2A (PP2A), an important component of AKT/GSK3 signaling implicated in a number of psychiatric disorders, including depression and bipolar disorder (Beaulieu, 2012), as well as response to psychotropic drugs, including antidepressants and lithium (Beaulieu et al., 2009).