A statistical evaluation revealed that several alleles of NRG1, HTR2C, and PIP4K2A are associated with a number of clinical subphenotypes of depression and bipolar disorder, namely, time to recurrence of a depressive episode and of manic or mixed episode, response to pharmacological antidepressant treatment on the 28th day assessed by the Hamilton Depression Rating Scale—17 items (HDRS-17) or the Clinical Global Impression – Improvement (CGI-I) scale, and severity of depression. This evidence concerns the gene NRG1 and depressive symptom measurement.