Among 3,090 patients with breast cancer in the cBioPortal database, only 25 (25/3,090) had somatic PALB2 mutations; 20 were missense mutations and five were high-risk mutations, including four stop-gain mutations (E12∗, E667∗, Q1146∗, and Q822∗) and one frameshift mutation (I1035Mfs∗6). Here, PALB2 is linked to breast cancer.