STIP1 and brain ischemia: In mice, HOP/STI1 is strictly required during embryo development, meanwhile different attempts to reduce the expression of HOP/STI1 in adult mice revealed multiple phenotypes, including increased sensitivity to cerebral ischemia, reduced hippocampal neuronal resilience during aging, reduced attention and increased hyperactivity (Beraldo et al., 2015; Lackie et al., 2017).