After B-H adjustment, in addition to the parameters mentioned above, pSS patients with late onset displayed also more frequently dry eyes, peripheral neuropathy, involvement of the central nervous system, sclerosing cholangitis and cryoglobulinemia, and, less commonly, arthralgia/myalgia, lymphadenopathy, anti-La, anti-Ro/La, and rheumatoid factor compared to their matched middle-aged controls (Table 3). This evidence concerns the gene CALR and peeling skin syndrome.