showed that in a lung cancer metastatic model, C5aR1 blockage resulted in decreased lung metastasis due to reduced TGF-b and IL-10 production by myeloid-derived suppressor cells since both TGF-b and IL-10 induced regulatory T-cell generation and facilitated an immunosuppressive Th2-based T cell responses (38). This evidence concerns the gene TGFB1 and lung cancer.