Knockdown of the c-Met protein can make tumor necrosis factor related apoptosis-inducing ligand (TRAIL)-resistant brain tumor cells sensitive to TRAIL treatment in vitro; moreover, in nude mice intracerebrally implanted with a c-Met-knockdown tumor cell line, the effect of stem cell-delivered S-TRAIL in vivo was confirmed using BLI (133). This evidence concerns the gene TNFSF10 and brain neoplasm.