In a more detailed analysis of intestinal immune responses initiated during live infection or by experimentally delivering S. mansoni eggs into different sites within the intestine itself, we furthermore show that distinct levels of type 1 and type 2 immune responses develop in the individual draining MLNs, with higher ratios of IFN-γ responses associated with infection/immunization of the large compared to the small intestine. This evidence concerns the gene IFNG and infection.