In a preclinical model of psoriasis, TRPA1 antagonists significantly inhibited itching, however it Is important to note that long term treatment with a TRPA1 antagonist or TRPA1 deletion is actually associated in increased psoriasis skin phenotype (210).The differences in long term vs. short term treatment may be linked to TRPA1 on other cell types, as additional studies have shown a role for TRPA1 on immune cells (71, 210–212). This evidence concerns the gene TRPA1 and psoriasis.