Except for some polymorphisms of TLR2, 3, 4, 8, and 9 (19–24), there have been only two reports on HIV infection with exonic TLR7 Gln11Leu, which shows a relation to the diminution of IFNα induction, but this polymorphism rs179008 is absent in Chinese Han people (45). The gene discussed is TLR7; the disease is HIV infectious disease.