Additionally, Th1 cells producing TNFα, IFNγ, IL-8, IL-12, CCR5, CXCR3, and MCP-1 (macrophage chemoattractant protein 1) were reported in several BD lesions, including oral and genital ulceration, pseudofolliculitis, pathergy pustules and bowel ulcers (88, 96). This evidence concerns the gene CXCL8 and Behcet disease.