In particular, the authors postulated the existence of a positive feedback loop, according to which Th1 cells localize proximal to tumoral vessels and change the local tumor microenvironment via CKs like IFNγ, which induces a reduction in VEGF-A production and an increase in Th1- and pericyte-recruiting chemokines CXCL9, CXCL10, CXCL11 (47). Here, VEGFA is linked to neoplasm.