ANGPT2 and neoplasm: Tumor cells can then induce endothelial activation mediated by CKs including Angiopoietin-2, which are responsible for the autocrine induction of STAT3 signaling in the endothelium, followed by the expression of chemokines (CCL2) and adhesion molecules (ICAM1) that recruit CCR2+ macrophages to the cancer site (37).