KLRK1 and neoplasm: NKG2D delivered signals via phosphorylated DAP10, contributing to the expression of downstream signaling molecules, and, therefore, playing a cytotoxic role; this research also demonstrated that the transduced NK cells were more cytotoxic to tumor cells than mock-transduced NK cells and that NKG2D triggered signal transduction and increased cytokine secretion of NK cells (42).