Interestingly, tumor eradication induced by only two infusions of ERBB2-CAR CIK cells enabled survival of the ERBB2-CAR CIK cells, but also led to the expansion and persistence of immune cell subpopulations, namely CD3+CD4+ helper T cells, CD3−CD56+ NK cells, and CD3+CD56+ T-NK cells, which had only been found in very low numbers within the adoptively transferred heterogeneous CIK cell population at the time of infusion (Figures 4A,B, Supplementary Figures 1E,F). Here, ERBB2 is linked to neoplasm.