CDH1 and atopic eczema: The finding that E-cadherin-KLRG1 ligation on human ILC2 reveals a significant decrease in GATA3 expression and type 2 cytokine (such as IL-5 and IL-13) release and the discovery that E-cadherin expression is suppressed in keratinocytes propose that inhibited E-cadherin expression may activate ILC2, promoting atopic dermatitis (AD) immunopathogenesis (28).