Many of these IRGs have be shown to be related to cancer development and prognosis, expression of serine/threonine kinase 1 promotes melanoma metastasis (47), serum levels of C-C motif chemokine ligand 17 (CCL17) are an independent prognostic marker of distant metastasis of melanoma, and patients with 43% of patients with high CCL17 levels survived to 3 years (48). This evidence concerns the gene CCL17 and melanoma.