In particular, STAT1 GOF and CVID patients with dysregulation exhibited low frequencies of cTfh17 but increased frequencies of cTfh1 cells, reduced frequencies of Sw-MBL and hypogammaglobulinemia (with the exception of P1 that coursed with autoimmune hepatitis and hypergammaglobulinemia). This evidence concerns the gene STAT1 and common variable immunodeficiency.