Overall these data confirmed the evidence raised in the general population on a close relation between CD28null T cells percentage and CV events: circulating levels of CD4+CD28null T cells were expanded in a cohort of patients with unstable angina, provided a strong and independent predictor of mortality in patients with heart failure and were found as tissue-infiltrating T cells in unstable atherosclerotic plaques (37–40). Here, CD4 is linked to heart failure.