In addition, different clinical trials registered to evaluate the efficacy of pharmacological inhibitors of the NLRP3 inflammasome in treating COVID-19; include Colchicine (NCT04326790, NCT04322565, NCT04328480, NCT04322682), Hydroxychloroquine in combination with Azithromycin (NCT04339816, NCT04336332), Melatonin (NCT04409522), and Tranilast (ChiCTR2000030002); versus standard care. This evidence concerns the gene NLRP3 and COVID-19.