In this regard, the putative MHC-I binding TNA that induce CD4+ T cell responses (presumably via binding to Class II MHC (MHC-II) molecules) together with MHC-II binding TNA are useful helper epitopes as they are expressed by the same tumor cells as the TAA and therefore captured together by APC for cross presentation to both CD4+ and CD8+ T cells (72). This evidence concerns the gene CD4 and neoplasm.