Recently, PD-L1 promoter methylation has been shown to negatively correlate with PD-L1 mRNA and/or protein expression in multiple cancer types including acute myeloid leukemia (78), glioblastoma (112), melanoma (113), head and neck cancer (114), colorectal cancer (115) and prostate cancer (116). The gene discussed is CD274; the disease is Familial prostate cancer.