Another study also demonstrated that tumor cells expressing PD-L1 were refractory to Fas- and protein kinase inhibitor Staurosporine-mediated apoptosis (170), which could suggest that the intracellular motifs of PD-L1 may be involved in crosstalk with other signaling pathways; in particular signaling pathways that control tumor cell survival. The gene discussed is WEE1; the disease is neoplasm.