Taken together, the infection level-dependent response of socs1 and other putative IFN-/Cytokine-inducible transcripts (irg1 and gvinp), as well as pathway enrichment results, suggest that the JAK-STAT pathway may be an essential part of host-pathogen interactions between Atlantic salmon and R. salmoninarum (Figure 12). Here, SOCS1 is linked to infection.