TNFSF11 and postmenopausal osteoporosis: Notably, previous reports on the effect of B cells and the B-cell-expressed RANKL on bone remodeling were performed in female mice, primarily because of the relevance to postmenopausal osteoporosis (11, 45, 46) and the results indicated that B cells mediate, at least in part, the effect of estrogen on bone mass.