However, homologous FIPs from different sources could display diverse activities and anti-tumor mechanisms, for example, FIP-gts from Ganoderma tsugae induces premature senescence of A549 lung cancer cells, while LZ-8 from Ganoderma lucidum increases A549 G1 arrest, and FIP-sch3 (FIP from Stachybotrys chartarum) induces A549 apoptosis and inhibits migration (36, 43, 44). The gene discussed is USF2; the disease is lung cancer.