IFNG and colorectal cancer: IFNγ KO mice have 37 specific down-regulated innatome pathways, seven specific up-regulated innatome pathways, and four common pathways shared by both promoted and suppressed programs including cardiac hypertrophy, integrin-linked kinase (ILK), role of NFAT in regulation of the immune response and colorectal cancer metastasis signaling (Figure 3).