The results showed that proinflammatory TFs deficiencies-downregulate four pathways (systemic lupus erythematosus in B cell signaling, interferon signaling, activation of IRF by cytosolic pattern recognition receptors, and endothelin-1 signaling) suggesting that these four pathways are promoted by the four TFs. This evidence concerns the gene TRIM63 and systemic lupus erythematosus.