IFNγR1 KO mice have 11 specific downregulated innatome pathways, 49 specific upregulated innatome pathways and 11 common pathways shared by both IFNγR1-promoted and suppressed programs including NF-kB, neuroinflammation, high mobility group box 1 (HMGB1), Toll-like receptors, production of reactive nitric oxide and ROS in macrophages, IL-1, cardiac hypertrophy, dendritic cell maturation, PI3K signaling in B cells, colorectal cancer metastasis, and cardiac hypertrophy (enhanced) (Figure 4). The gene discussed is HMGB1; the disease is cardiac hypertrophy.