IL36G and bacterial pneumonia: On the one hand, IL-36γ secreted via packaging within microparticles and played a vital proximal role in lung innate mucosal immunity during bacterial pneumonia via induction of type-I cytokine responses and polarization of classical macrophage (11); on the other hand, IL-36γ derived from alveolar epithelial cells and pulmonary macrophages during Pseudomonas aeruginosa infection yet contributes to deleterious effects on host immune response (12).