IL1RL2 and influenza: Therefore, it is reasonable to infer that the higher expression of IL-36R in the APC during influenza infection is essential stress feedback of the host and contributes to adapting to the “long-term persistent infection.” It is worthwhile to note that IL-36R protein can also be detected in the surface of B lymphocytes, and the percentage of IL-36R+ B cells in B cells pool in severe influenza patients is about 40% higher than controls.