NLRC4 and tuberculosis: On the other side, and for the first time to our knowledge, we observed that the loss-of-function variants in NLRC4 (rs479333), which did not affect susceptibility to TB per se (padj = 0.658), results significantly less frequent in patients with the more severe form of infection (extra-pulmonary TB) compared to pulmonary TB, according to a dominant model of inheritance for the minor C allele (G/C+C/C: 0.40 vs. 0.61) (Table 3).