Altogether, these findings corroborate previous data about the importance of NLRP3 in macrophage' response against virulent Mtb (10–12, 17, 31, 32), including at physiologic condition of infection (MOI: 0.033), and support the protective effect observed for NLRP3 rs10754558 against the development of active pulmonary TB (18). The gene discussed is NLRP3; the disease is infection.