In naïve CD4 T cells, non-cTfh cells (CXC5RnegCD45RAneg) or cTfh cells (CXCR5posCD45RAneg) the proportions of CXCR3posCCR6neg, CXCR3posCCR6pos, CXCR3negCCR6pos, or CXCR3negCCR6neg T cells were not significantly altered compared to unstimulated T cells after co-culture with either CD21low B-cell subpopulations of patients or the CD21pos counterparts of HD corroborating the findings of cytokine profiles (Supplementary Figure 4B). The gene discussed is CD4; the disease is Huntington disease.