A previous study has described that EMPs from idiopathic pulmonary fibrosis patients stimulated the migration of normal human lung fibroblast (32) and other reports suggest direct implication of MP in fibrosis genesis, through their content or their surface markers [DAMPs, metabolite implied in the ROS production or nuclear factor B pathway, plasmin expression etc.; (33)]. Here, PLG is linked to idiopathic pulmonary fibrosis.