Conversely, MPs from SSc patients upregulated Col1a1 (mean ± sem of fold change for 10 MPs/μl: 1.41 ± 0.37; for 100 MPs/μl: 2.03 ± 0.35; for 1,000 MPs/μl: 2.47 ± 0.7, Figure 3A) and Col1a2 expression (mean ± sem of fold change for 10 MPs/μl: 3.74 ± 1.00; for 100 MPs/μl: 6.56 ± 1.95; for 1,000 MPs/μl: 8.32 ± 3.32, Figure 3B) in a dose dependent manner. Here, COL1A1 is linked to systemic sclerosis.