We detected HWE violation in IL6−174 rs1800795 C>G in patients with detectable T. cruzi DNA in peripheric blood; in patients without cardiopathy (IL17 rs2275913 G>A and IL18 −137 rs187238 C>G) and in patients with cardiopathy (IL1B rs1143627 T>C); in individuals with NYHA < 2 (NYHA 1) or without heart failure (IL17 rs2275913 G>A and IL18−607 rs1946518 C>A); and in subjects with NYHA ≥ 2 (IL1B rs1143627 T>C) (Supplementary Table 2). The gene discussed is IL18; the disease is heart failure.