Clear cell renal carcinoma: Promotes PI3K/AKT signaling (CXCR5+) Model: human tissue analysis (14) Prostate cancer: Enhances ECM remodeling and bone metastasis (CXCR5+) Model: human engineered cell lines and xenograft mouse model (76). The gene discussed is CXCR5; the disease is clear cell renal carcinoma.