Co-immunization with α-GalCer, KBC-007 and KBC-009 increased PR8-specific systemic IgG and mucosal IgA. α-GalCer and KBC-009 (but not KBC-007) increased antigen-specific lymphocyte proliferation, cytokine production, and cytotoxic CD8+ T cell activity and induced complete protection from live virus infection. The gene discussed is CD8A; the disease is viral infectious disease.