FBXW7 and non-small cell lung carcinoma: In patients with chronic myeloid leukemia and non-small cell lung cancer, ablation of F-box/WD repeat-containing protein 7 (FBXW7), a ubiquitin ligase that regulates dormancy by degrading cMyc and Notch (291), pushes CSCs out of dormancy and thus significantly enhances the benefit of imatinib and gefitinib, respectively (292, 293).