More precisely, dormant cells were shown to reside predominantly close to perisinusoidal venules expressing high levels of the inflammatory vascular cell adhesion molecule E-selectin, which favors the entry of cancer cells into the BM, and of the stromal cell-derived factor 1 (SDF-1), which anchors cells to the niche through its interaction with the C-X-C chemokine receptor type 4 (CXCR4), respectively (160). This evidence concerns the gene CXCR4 and cancer.