SIAH2 and Familial prostate cancer: The Wnt pathway, which in its canonical form acts as a regulator of processes like cell proliferation and cell stemness (141), is also inversely associated with cancer cell dormancy (107, 142), was reported to induce dormancy of prostate cancer cells populating the BM niches, via a mechanism involving the non-canonical receptor tyrosine kinase-like orphan receptor 2 (ROR2)/Siah E3 Ubiquitin Protein Ligase 2 (SIAH2) signal, resulting in the inhibition of the canonical Wnt/β-catenin pathway (143).