For instance, in the mouse model, the plasmacytoid dendritic cells (pDCs) has been shown to be the main source of type I interferon during AIV infection (Jewell et al., 2007), the effective detection of AIV by pDCs can improve the quality of the immune response and induce a more effective antiviral level at early stage, however, it also can limit the T cell response by inhibiting the Fas-dependent apoptotic pathway, leading to an increase in mortality from lethal infections (Langlois and Legge, 2010). Here, FAS is linked to infection.