ASPG and acute lymphoblastic leukemia: L-asparaginase has been applied widely in medical applications, the treatment of diseases (e.g., acute lymphoblastic leukemia, non-Hodgkin’s lymphoma and acute myeloid leukemia), and the reduction of carcinogenic acrylamide in food industries (Boyse et al., 1967; Narta et al., 2007; Pedreschi et al., 2008; Costa et al., 2016).