There were 11 upregulated TFs that were co-activated in both acute and chronic infections (Table 2), which functioned as regulators for shared target genes (interaction lines with purple color); of which, Irf1 and Stat1 also can regulate two exclusive target genes in early infection (interaction lines with orange color); and as shown in Figure 4, 35 TFs except Eif2ak2 and Irf9 were involved in more interactions together with the corresponding target genes in late stage of infection (interaction lines with blue color). The gene discussed is IRF9; the disease is infection.