GSDME and infection: In the present study, we detected nine pyroptosis-related DETs in the infected brain, including three (Casp4, Gsdmd, and Pycard) that were upregulated in both early and late infections; five (Casp1, Naip2, Naip5, Naip6, and Nlrp1b) were upregulated and one (Gsdme) was downregulated in chronic infection.