On the other hand, Staphylococcus aureus, usually as a potential pathogen, was found to be overgrown in atopic dermatitis (AD; Chng et al., 2016; Geoghegan et al., 2018) and could bind to TLR2 heterodimers to initiate long-lasting cutaneous inflammation (Biedermann et al., 2015). Here, TLR2 is linked to Alzheimer disease.