A common feature of anabolic HBM is activation of the Wnt/β-catenin signaling pathway, with increased signaling through this pathway underlying the phenotype of sclerosteosis, van Buchem’s disease, LRP4 HBM, LRP5 HBM, and LRP6 HBM (all discussed below). The gene discussed is LRP4; the disease is hyperostosis corticalis generalisata.