Only one case of Glanzmann thrombasthenia has been reported with a bone phenotype, with generalized and skull base osteosclerosis observed on plain radiographs of a 5 day old baby (252), termed osteopetrosis and thought due to impaired osteoclast function (253). A similar platelet phenotype has been associated with osteopetrosis (reported in three cases) in the presence of mutations in Kindlin-3 (MIM612840), coding for Kindlin-3 which also interacts with β-integrins. This evidence concerns the gene FERMT3 and Glanzmann thrombasthenia 1.