TPO and spindle cell hemangioma: In an observational study of postmenopausal women in the Netherlands, those with SCH had an increased prevalence of myocardial infarction [odds ratio (OR) 2.3, 95% confidence interval (CI) 1.3–4.0]; this risk was even higher among those with positive serum TPO antibodies (OR 3.5, 95% CI 1.7–7.4) (30).