Indeed, when LCMV-infected RIP-LCMV mice receive an additional virus infection that grows to high titers in the lymph nodes causing a high local concentration of CXCL10, islet antigen-specific T cells accumulate in the infected lymph nodes and are driven to apoptosis by hyperactivation, resulting in an abrogation of T1D (57). The gene discussed is CXCL10; the disease is type 1 diabetes mellitus.