The expression of genes involved in cholesterol homeostasis, HMGCR (Hmgcr), sterol regulatory element-binding protein 2 (Srebf2) and low density lipoprotein receptor (Ldlr) significantly decreased in animals fed with WD-CA (P< 0.01, P<0.001 and P<0.05). The gene discussed is HMGCR; the disease is Wilson disease.