In conclusion, our research shows that M2 macrophages, Tregs, monocytes, neutrophils, DCs, MCs, and M0 macrophages play a tumor-promoting role in PTC, while M1 macrophages, CD8+ T cells, B cells, NK cells, TFH cells (eosinophils, γδ T cells, and Th17 cells with weak supporting evidence) play an antitumor role. This evidence concerns the gene CD8A and neoplasm.