In addition, the pathway enrichment analysis revealed that these target genes were primarily mapped into cytokine-cytokine receptor interaction, osteoclast differentiation, PI3k-Akt signaling pathway, TNF signaling pathway, IL-17 signaling pathway, NF-κB signaling pathway, rheumatoid arthritis, and so on (Figures 7A–C). The gene discussed is TNF; the disease is rheumatoid arthritis.