DKK1 and osteoporosis: For instance, dickkopf-1 (DKK1), a powerful antagonist of canonical WNT signaling pathway and biomarker for osteoporosis, was predicted as the shared targets of hsa-miR-133b, -20a-5p, -637, -214-3p, -106a-5p, and -135b-5p in our study.