TNF and rheumatoid arthritis: Moreover, functional enrichment analysis demonstrated that these miRNAs and their target genes were mainly enriched in GO terms and pathways related to bone and immune system: GO terms like bone remodeling, skeletal system development, bone mineralization, T cell activation, and Th17 cell differentiation; pathways such as cytokine-cytokine receptor interaction, osteoclast differentiation, TNF signaling pathway, PI3K-Akt signaling pathway, rheumatoid arthritis, and IL-17 signaling pathway.