While there are reports of hearing loss and vertigo relating to its use, too many variables including medical condition treated, concomitant treatments, electrolyte imbalance, dosage, blood levels, cytochrome P-450 metabolism, duration of treatment and pre-existing hearing impairment limit me in being able to state that cyclosporine is in fact an ototoxic medication. This evidence concerns the gene CYP4F3 and hearing loss disorder.