In male SVD patients (Figure 3A, Table 5A), alternatively spliced genes included: cytochrome P450 family 4, subfamily F, member 2 (CYP4F2), a previously GWAS identified SVD risk gene (10) as well as HDAC9, LPAL2, NINJ2, SORT1, and WNK1. This evidence concerns the gene CYP4F2 and snowflake vitreoretinal degeneration.