This expansion results in the methylation and subsequent silencing of the FMR1 gene, leading to drastically reduced levels of FMRP, the protein product of FMR1. The amount of FMRP produced in an individual directly correlates with his or her degree of cognitive impairment, with higher levels found in affected individuals with IQ scores above 70 (7, 8). This evidence concerns the gene FMR1 and Cognitive impairment.