An increased level of circulating MCP-1 is associated with increasing the long-term risk of ischemic stroke (102), and the infiltration of CCR2+ monocytes is greatly diminished in mice with dysfunctional CX3CR1-CCR2 signaling, resulting in the attenuation of acute injury in a rodent model of childhood stroke (61). The gene discussed is CCL2; the disease is ischemic stroke.