Importantly, TIM-4 expression levels in non-classical monocytes are highly correlated with NIHSS scores 2 days after stroke and are significantly increased in patients with AIS and poor outcomes, suggesting that the percentage of TIM-4 expression in non-classical monocytes could be a biomarker in predicting the clinical course and prognosis in AIS (134) (Table 2). This evidence concerns the gene TIMD4 and stroke disorder.