IGF1 and ischemic stroke: To discover novel methods of ischemic stroke therapy, factors related to inflammation in the brain, such as C-reactive protein (CRP) (124), hepatocyte growth factor (125), insulin-like growth factor-1 (IGF-1), IGF-binding protein-3 (126), factor XIII (127), brain-derived neurotrophic factor (128), and d-dimer (129), have been investigated.