C-C motif ligand 5 (CCL5) inhibition induced by the addition of MKEY, an antagonist of CXCL4-CCL5 heterodimer formation, was shown to significantly reduce the infiltration of Ly6C+ monocytes, resulting in the attenuation of classical monocyte-mediated neuroinflammation in a model of experimental ischemic stroke (109). Here, CCL5 is linked to ischemic stroke.