About 25% of patients with chronic rhinosinusitis develop CRSwNP (93) In the “SINUS” 24%2 study Dupilumab, a human monoclonal antibody that blocks a shared receptor component of interleukin 4 and 13 improved the sense of smell in patients with severe CRSwNP (94). Here, IL4 is linked to chronic rhinosinusitis with nasal polyps.